Dr. Adel Pezeshki
Dr. Pezeshki's research focuses on nutritional physiology. The energy balance regulation and changes in body weight and body composition are dependent on controls operating on both food intake and energy expenditure. I have a general research interest in animal metabolism and energy balance regulation, especially as applied to the mechanisms regulating energy expenditure. The overall goal of my research program is to identify novel regulators of thermogenesis and to characterize the pathways by which these key molecules coordinate adaptive changes in energy expenditure and metabolism. An understanding of the underlying mechanisms regulating energy expenditure is critical for developing novel strategies to mitigate health disorders such as obesity in companion animals, as well as for improving feed efficiency and productivity in agricultural species.
Dr. Leon Spicer
Dr. Spicer’s research endeavors involve a wide range of in vivo and in vitro approaches to study nutritional and hormonal control of ovarian function and follicular development. Experimental approaches span from evaluating control of steroidogenesis, mitogenesis and gene expression in ovarian cells to determining the effect of nutritional supplements on ovarian function and milk production in dairy cattle.
Dr. Spicer’s recent efforts have utilized microarray technology to discover genes involved in the control of ovarian function. Specifically, his laboratory has discovered several unique porcine granulosa cell genes stimulated by insulin-like growth factor 1, including thrombospondin and fibroblast growth factor 2 receptor. In addition, bovine granulosa cell gene expression in cystic and normal follicles were compared and several novel genes not previously identified in bovine follicles were discovered, including Indian hedgehog protein, brain ribonuclease, and fibroblast growth factor 9 (FGF9). This work has led to identification of possible roles for Indian hedgehog protein, brain ribonuclease, and FGF9 in ovarian follicular development in cattle.