University of Arkansas beef specialists conducted an experiment to
compare the clostridial antibody response of 8 month-old heifers that do
develop OR do not develop visible injection-site lesions and swelling.
Blood samples were collected on day 0, 28, 56, 84, and 112 after injection
with a 7-way clostridial subcutaneous vaccination. The vaccinations
were given in the neck with a pistol-grip syringe using the tented technique.
Heifers with lesions (64.9%) actually had elevated antibody titers for
Clostridial chauvoei (blackleg) on day 28 and day 84 compared to heifers
without lesions or swelling. Clostridium sordelli and Clostridium
perfringens antibody titers were higher in heifers with lesions
on day 28 and day 56. Consequently, the presence of an injection-site
lesion or swelling following a clostridial vaccination may not have visual
appeal but may have positive implications for immune response. Source:
Troxel and co-workers. 2001 University of Arkansas Animal Science Research
Report.
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